Endocrine Abstracts

To clarify the role of the pituitary in zebrafish interrenal development we investigated wildtype (wt) zebrafish and 3 pituitary mutants: aal (with lactotrophes only), and pit1 (with corticotrophes only), fgf3-lia (lacking all adenohypophyseal cell types) and in MC2R knockdown embryos (MC2R morphants).The interrenal primordium (IP) is detectable at 22hpf (hours post fertilization) as bilateral clusters of ff1b expressing cells which fuse to one domain at...

Sporadic somatostatinomas are rare neuroendocrine tumours (NETs), classically presenting with hyperglycaemia, cholelithiasis and steatorrhoea. The mainstay of treatment is surgical resection; other aspects of management remain uncertain. We report 3 cases. Case 1: A 55 year-old female presented with abdominal discomfort and steatorrhoea. Computed tomography (CT) demonstrated a 9 cm pancreatic mass. Biopsy suggested a NET. Somatostatin (SMS) was 160 pmol/l (normal 0-150)...

Background: Minimally invasive parathyroidectomy relies on accurate localisation of the culprit gland. Combination of US plus Technetium 99m-sestamibi is considered the gold standard. CT parathyroid is thought to be a valuable tool in the pre-operative localisation.Aim: To evaluate the diagnostic performance of 2D CT parathyroid in patients with primary hyperparathyroidism (PHP).Methods: This was a single-institution prospective st...

Avoiding vitamin D deficiency can be beneficial in prevention of adverse maternal, fetal and neonatal outcomes. Because of increasing level of vitamin D-binding protein (DBP) in pregnancy, the determination of free-25OHD should be required, whose adequate measure is a challenge for the analytics. Literature data are contradictory whether total-or free-25OHD fraction is more reliable taking into consideration the methods of measurement. Data of publications on free or total, bi...

Vitamin D deficiency is common in patients with chronic renal failure (CRF) based on routinely determined total-25-hydroxyvitaminD (t-25OHD) levels. The present knowledge is contradictory whether the direct measured free-25OHD (dm_f-25OHD) or the calculated free-25OHD (c_f-25OHD) is the best indicator of the vitamin D supply for CRF patients. Adding methods to our previously described first experiences on this subject, in this study we aimed to serve newer data to make this qu...